Blood Lactate: Biochemistry, Laboratory Methods, and Clinical Interpretation
作者:
ToffalettiJohn G.,
期刊:
Critical Reviews in Clinical Laboratory Sciences
(Taylor Available online 1991)
卷期:
Volume 28,
issue 4
页码: 253-268
ISSN:1040-8363
年代: 1991
DOI:10.3109/10408369109106865
出版商: Taylor&Francis
关键词: blood lactate;hypoxia;glycolysis;oxygen delivery
数据来源: Taylor
摘要:
AbstractWith the renewed awareness of blood lactate as an indicator of circulatory impairment, there has been much interest in the use of lactate measurements to determine the overall state of oxygenation of patients in critical care. This review begins by covering the areas of lactate homeostasis and biochemistry, both of which are essential for fully understanding the interpretation of lactate measurements. Then, the clinical interpretation of lactate measurements includes sections on the causes and treatments of hemodynamic deficits leading to lactic acidosis, the classification of lactate abnormalities, and the use of lactate measurements in critical care monitoring, including surgery. Both the principles and the latest developments in lactate methodology are covered, including the new whole blood analyzers. This review concludes with reference intervals and guidelines to the interpretation of results.
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