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Interaction between Antipyrine and the Microsomal Ethanol Oxidation in Rat Liver

 

作者: P.B. Andreasen,   A. Bremmelgaard,   B.K. Larsen,  

 

期刊: Pharmacology  （Karger Available online 1974）
卷期: Volume 12, issue 4-5  

页码: 244-250

 

ISSN:0031-7012

 

年代: 1974

 

DOI:10.1159/000136546

 

出版商: S. Karger AG

 

关键词: Antipyrine;Ethanol oxidation;Hepatic microsomes

 

数据来源: Karger

 

摘要:

The kinetics of hepatic microsomal ethanol oxidation (MEOS) was studied in microsomal suspension from rat liver. The estimated maximum elimination rate was 117 nmol acetaldehyde/ min/g liver and the half-saturation concentration 12.7 mmol ethanol/l. The MEOS activity was not influenced by the presence of antipyrine 0.1 mmol/l and 1.0 mmol/l in the microsomal incubations.

 

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