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Intra-arterial Cereport (RMP-7) and Carboplatin: A Dose Escalation Study for Recurrent Malignant Gliomas

 

作者: Timothy Cloughesy,   Keith Black,   Y. Gobin,   Keyvan Farahani,   Gillian Nelson,   Pablo Villablanca,   Fairooz Kabbinavar,   Fernando Viñeula,   Cornelius Wortel,  

 

期刊: Neurosurgery  (OVID Available online 1999)
卷期: Volume 44, issue 2  

页码: 270-278

 

ISSN:0148-396X

 

年代: 1999

 

出版商: OVID

 

关键词: Blood-brain barrier;Bradykinin;Brain tumor;Carboplatin;Glioma;Intra-arterial;RMP-7

 

数据来源: OVID

 

摘要:

OBJECTIVE:Animal and human studies have shown increased delivery of radiolabeled compounds across the blood-brain-tumor barrier using intra-arterial (IA) Cereport (RMP-7; Alkermes Inc., Cambridge, MA) with a radiolabeled tracer. This present study assesses the safety, tolerance, and preliminary efficacy of the IA administration of carboplatin with Cereport.METHODS:An open-label dose escalation study of IA Cereport (10-300 ng/kg) with 100 mg of IA carboplatin was conducted in 11 patients with recurrent malignant gliomas and 1 patient treated adjuvantly after radiation therapy. Tumor size and laboratory and clinical statuses were assessed.RESULTS:Adverse events were mainly neurological in nature and corresponded to the anatomic location of the tumor. Karnofsky performance scale scores did not decline, overall, for those patients who had tumor response. Tumor shrinkage was observed in three of six evaluable patients who received a dose of 300 ng/kg with durable responses of 60, 64, and 106+ weeks.CONCLUSION:Previous studies have demonstrated increased permeability in human gliomas using IA Cereport. This study demonstrates durable imaging responses using 100 mg of IA carboplatin in combination with Cereport. The drug combination in this patient population seems to be safe and acceptable, providing a novel means of antitumor dose intensification.

 



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