Compensatory Adrenal Growth is Neurally Mediated
作者:
W.C. Engeland,
M.F. Dallman,
期刊:
Neuroendocrinology
(Karger Available online 1975)
卷期:
Volume 19,
issue 4
页码: 352-362
ISSN:0028-3835
年代: 1975
DOI:10.1159/000122456
出版商: S. Karger AG
关键词: Rats;Unilateral hypothalamic lesions;Unilateral adrenalectomy;Adrenal nerves
数据来源: Karger
摘要:
We have tested the possibility that compensatory adrenal growth is neurally mediated. Small unilateral electrolytic lesions were made in the ventral hypothalamus of young male rats. Subsequently, unilateral adrenalectomy was performed on the side ipsilateral or contralateral to the hypothalamic lesion. Four days later the animals were killed and the remaining adrenal was weighed; the location and extent of the hypothalamic lesions were determined. Lesions placed on the same side as adrenalectomy prevented compensatory growth of the remaining gland (p < 0.005), while lesions on the side opposite to the removed adrenal did not interfere with compensatory adrenal growth. We conclude from these findings, and from a review of some anatomical studies, that compensatory adrenal growth is effected through a reflex that involves both afferent and efferent neural limbs.
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