Synthesis, purification, and properties of a peptide that enhances the activation of human [Glu1]plasminogen by tissue plasminogen activator and retards fibrin polymerization
作者:
BAKSHY A.K. CHIBBER,
SHOKO URANO,
FRANCIS J. CASTELLINO,
期刊:
International Journal of Peptide and Protein Research
(WILEY Available online 1990)
卷期:
Volume 35,
issue 1
页码: 73-80
ISSN:0367-8377
年代: 1990
DOI:10.1111/j.1399-3011.1990.tb00723.x
出版商: Blackwell Publishing Ltd
关键词: effectors of plasminogen activation;fibrin formation;profibrinolytic peptide
数据来源: WILEY
摘要:
Solid phase synthesis of the hexapeptide, GPRVVE, which represents the amino terminal six amino acids of the α‐chain of human fibrin, yielded a product that contained a modified glutamic acid. The nature of the modification was established as the Friedel‐Crafts acylation product of the peptide and anisole, the latter reagent employed in the HF deblocking step. The anisoylated peptide selectively enhanced the activation rate of native [Glu1]plasminogen by recombinant tissue plasminogen activator, accelerated clot lysis, and retarded the polymerization of nascent f
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