SynopsisAn experimental model using the ‘Rhino’ hairless mouse has been developed for screening comedolytic agents.The skin of this animal presents a high density of spontaneous comedos which appear in histological slices as cystic formations with a large diameter (D) and an open narrow neck (d). The ratio d/D expresses the ‘comedo profile'. Statistical evaluation of this value by standardized measurement allows the quantification of comedolytic activity of pharmacological agents.Un nouveau modèle pour la mesure de l'activité comé