Biotransformation of Drugs during Aging
作者:
J.R. Kiechel,
期刊:
Gerontology
(Karger Available online 1982)
卷期:
Volume 28,
issue 1
页码: 101-112
ISSN:0304-324X
年代: 1982
DOI:10.1159/000212577
出版商: S. Karger AG
关键词: Phase 1;Phase 2 reactions;Induction;Intrinsic clearance;Liver mass;Influence of age
数据来源: Karger
摘要:
Wherever the age of an individual can, of course, be precisely indicated, the individual physiological state of every aged person varies greatly and therefore the resultant implications considering absorption, distribution, metabolism and excretion. In animals aging has been described as a factor of modification of metabolism. In the elderly the oxida-tive enzyme activity appears diminished but coupled to a decreased liver mass and liver blood flow. Examples of decreased conjugation for paracetamol and indomethacin are known. Ace-tylation does not seem to be influenced. The net effect of aging appears quite frequently an increase in the blood level of unchanged drug. However, drug metabolism cannot be considered independently from the other factors calling for an individualized treatment of the elderly.
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