Effects of Some Polyene Antibiotics on Human Platelets and their Function
作者:
P.M. van der Plas,
L. Kraan,
J. Stibbe,
H.C. Hemker,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1972)
卷期:
Volume 1,
issue 3-4
页码: 175-190
ISSN:1424-8832
年代: 1972
DOI:10.1159/000213984
出版商: S. Karger AG
关键词: Polyene antibiotics;Blood platelets;Platelet aggregation;Platelet factor 3;Serotonin uptake
数据来源: Karger
摘要:
(1) Polyenes aggregate platelets. The aggregation power diminishes in the following order: filipin > nystatin > etruscomycin∼pimaricin. (2) In the case of filipin, aggregation is probably caused by damage to platelets resulting in a release of platelet contents, which subsequent aggregates the remaining platelets. (3) Filipin-induced aggregation can be partially inhibited by adenosine and is Ca++ pimaricin. (6) The uptake of serotonin by platelets is diminshed by polyenes. Leakage of 86Rb from preloaded platelets increases upon addition of polyene
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