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Suppression of Testicular Androgen Synthesis in the Rat by Ethylene Dimethanesulphonate

 

作者: Denise E. Bu’;Lock,   Marion Jackson,  

 

期刊: Gynecologic and Obstetric Investigation  （Karger Available online 1971）
卷期: Volume 2, issue 1-6  

页码: 305-308

 

ISSN:0378-7346

 

年代: 1971

 

DOI:10.1159/000301872

 

出版商: S. Karger AG

 

关键词: Ethylene dimethanesulphonate;Testosterone;Antispermatogenic;4-14C-progesterone

 

数据来源: Karger

 

摘要:

In the rat the antispermatogenic and anti-fertility effects of ethylene dimethanesulphonate (EDS) are associated with temporary involution of accessory glands. Using 4–14C-labelled progesterone it has been shown in vitro that marked and dose-dependent inhibition of testosterone synthesis occurred over a time range consistent with the duration of sterility. The results also indicated that the metabolism of pregnenolone and 17α-hydroxyprogesterone are impaired.

 

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