SummaryReviewing briefly the outstanding publications and the scheduled facts on«Xanthomatosis»the author describes a personal case of Multiple Xanthomatosis, associating tendon xanthoma, xanthoma tuberosum and planum. His study gives a complete analysis of the clinical features, pathogenesis, chemical and histological findings and mentions the influence of nutrition on the disease.Emotional factors have not to he neglected. The highest free-cholesterollevel published to-day was found by a chemical analysis of a xanthoma of this patient.