Agnatasterone A and B, Unusual Pregnane Steroids Isolated from the North‐East Atlantic SpongeAxinella agnata
作者:
Graziano Guella,
Francesco Pietra,
期刊:
Helvetica Chimica Acta
(WILEY Available online 1988)
卷期:
Volume 71,
issue 1
页码: 62-71
ISSN:0018-019X
年代: 1988
DOI:10.1002/hlca.19880710108
出版商: WILEY‐VCH Verlag GmbH
数据来源: WILEY
摘要:
AbstractTwo novel pregnatrienolones isolated in very small amounts from the North‐East‐Atlantic demospongeAxinella agnata(Tetractinomorpha, Axinellida) are unique in having C(2)C(3) (or C(3)C(4)), C(7)C(8), and C(16)C(17) bonds and a 12β‐OH group which, being strongly H‐bonded to a 20‐keto group, resists acylation.1H‐ and13C‐NMR spectroscopy of the steroids and of products of their selective epoxidation or reduction allow us to propose the structures (+)‐12β‐hydroxy‐5α‐pregna‐2,7,16‐trien‐20‐one ( = agnatasterone A, (+)‐1), and (+)‐12β‐hydroxy‐5α‐pregna‐3,7,16‐trien‐20‐one ( = agnatasterone B. (+)‐5),
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