Acute Tolerance to the Analgesic Action of Nitrous Oxide Does Not Develop in Rats
作者:
Koh Shingu,
Masami Osawa,
Kazuhiko Fukuda,
Kenjiro Mori,
期刊:
Anesthesiology
(OVID Available online 1985)
卷期:
Volume 62,
issue 4
页码: 502-504
ISSN:0003-3022
年代: 1985
出版商: OVID
关键词: Analgesia: tolerance;Anesthetics;gases: nitrous oxide;Tolerance: nitrous oxide
数据来源: OVID
摘要:
The time course of nitrous oxide analgesia was studied in rats with a behavioral criterion, the tail-flick test to radiant heat. All rats were placed individually in a Plexiglas® tube and exposed to either nitrous oxide, 75% in oxygen, or room air (control) for 2 hr. Analgesic potency was evaluated by prolongation of the time required to induce tail-flick. Although individual animals showed variability in the tail-flick time during exposure to nitrous oxide, no animal showed a tendency toward the development of tolerance, and a statistically significant sustained prolongation of tail-flick time was produced.
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