Idiopathic Environmental IntolerancePart 1: A Causation Analysis Applying Bradford Hill's Criteria to the Toxicogenic Theory
作者:
Herman Staudenmayer,
Karen E Binkley,
Arthur Leznoff,
Scott Phillips,
期刊:
Toxicological Reviews
(ADIS Available online 2003)
卷期:
Volume 22,
issue 4
页码: 235-246
ISSN:1176-2551
年代: 2003
出版商: ADIS
关键词: Poisoning
数据来源: ADIS
摘要:
Idiopathic environmental intolerance (IEI) is a descriptor for a phenomenon that has many names including environmental illness, multiple chemical sensitivity and chemical intolerance. Toxicogenic and psychogenic theories have been proposed to explain IEI. This paper presents a causality analysis of the toxicogenic theory using Bradford Hill's nine criteria (strength, consistency, specificity, temporality, biological gradient, biological plausibility, coherence, experimental intervention and analogy) and an additional criteria (reversibility) and reviews critically the scientific literature on the topic. The results of this analysis indicate that the toxicogenic theory fails all of these criteria. There is no convincing evidence to support the fundamental postulate that IEI has a toxic aetiology; the hypothesised biological processes and mechanisms are implausible.
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