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Applying survival methodology to adverse experience occurrences in controlled clinical trials

 

作者: Enoch B. Bortey,   A. Lawrence Gould,  

 

期刊: Journal of Biopharmaceutical Statistics  (Taylor Available online 1991)
卷期: Volume 1, issue 1  

页码: 57-66

 

ISSN:1054-3406

 

年代: 1991

 

DOI:10.1080/10543409108835005

 

出版商: Marcel Dekker, Inc.

 

数据来源: Taylor

 

摘要:

On the basis of calculated cumulative hazard rates for initial occurrence of adverse experiences of patients following treatment for rheumatoid arthritis and osteoarthritis, a simple function is evolved that fits such cumulative hazard rate data very well. From this simple function, we obtain the estimated hazard rate in terms of two physically meaningful parameters. These two parameters can be used to describe the rate of occurrence of adverse experiences, and to convey the concept of risk of adverse experience associated with duration of exposure to a drug.

 

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