Twelve serum analytes [triglycerides, cholesterol, total and conjugated bilirubin, high‐density‐lipoprotein cholesterol (HDL‐C), alkaline phosphatase (AP), gammaglu‐tamyl transferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), β‐glucuronidase (β‐glu), alanine aminopeptidase (AAP), and 5’ ‐nucleotidase (5'nuc)] were measured to investigate their correlation with exposure to polychlori‐nated biphenyls (PCBs) and 1,1,1‐trichloro‐2,2‐bis(p‐chlorophenyl)ethane (DDT). The relationship between serum lipids, lipophilic toxicants, and the analytes was also evaluated. The β‐glu, 5'nuc, triglycerides, cholesterol, and total bilirubin correlated positively and significantly with log concentrations of serum total PCBs and 1,1‐di‐chloro‐2,2‐bis(p‐chlorophenyl)ethylene (DDE), a metabolite of DDT. The more highly chlorinated PCBs (Aroclor 1260) had significant, positive correlations with several serum analytes, but the less chlorinated PCBs (Aroclor 1242) correlated significantly and negatively only with HDL‐cholesterol.