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The Effects of Vagus Nerve Stimulation on Cognitive Performance in Patients With Treatment-Resistant Depression

 

作者: Harold Sackeim,   John Keilp,   A. Rush,   Mark George,   Lauren Marangell,   Jennifer Dormer,   Tal Burt,   Sarah Lisanby,   Mustafa Husain,   C. Cullum,   Nicholas Oliver,   Holly Zboyan,  

 

期刊: Neuropsychiatry, Neuropsychology & Behavioral Neurology  (OVID Available online 2001)
卷期: Volume 14, issue 1  

页码: 53-62

 

ISSN:0894-878X

 

年代: 2001

 

出版商: OVID

 

数据来源: OVID

 

摘要:

BackgroundChronic vagus nerve stimulation (VNS) is effective in the management of treatment-resistant epilepsy. Open-trial evidence suggests that VNS has clinically significant antidepressant effects in some individuals who experience treatment-resistant major depressive episodes. However, limited information regarding the effects of VNS on neurocognitive performance exists.ObjectiveThe primary aim of this study was to determine whether VNS leads to neurocognitive deterioration.MethodA neuropsychological battery was administered to 27 patients with treatment-resistant depression before and after 10 weeks of VNS. Thirteen neurocognitive tests sampled the domains of motor speed, psychomotor function, language, attention, memory, and executive function.ResultsNo evidence of deterioration in any neurocognitive measure was detected. Relative to baseline, improvement in motor speed (finger tapping), psychomotor function (digit-symbol test), language (verbal fluency), and executive functions (logical reasoning, working memory, response inhibition, or impulsiveness) was found. For some measures, improved neurocognitive performance correlated with the extent of reduction in depressive symptoms, but VNS output current was not related to changes in cognitive performance.ConclusionsVagus nerve stimulation in treatment-resistant depression may result in enhanced neurocognitive function, primarily among patients who show clinical improvement. Controlled investigation is needed to rule out the contribution of practice effects.

 

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