Tremorlytic Activity of BudipineA Quantitative Study with Long‐Term Tremor Recordings
作者:
S. Spieker,
P. Löschmann,
C. Jentgens,
A. Boose,
T. Klockgether,
J. Dichgans,
期刊:
Clinical Neuropharmacology
(OVID Available online 1995)
卷期:
Volume 18,
issue 3
页码: 266-272
ISSN:0362-5664
年代: 1995
出版商: OVID
关键词: Budipine;Parkinson's disease;Tremor;Long-term tremor recordings
数据来源: OVID
摘要:
The tremorlytic activity of the novel antiparkinson agent budipine was quantified in an open trial. Eleven patients with Parkinson's disease (PD) were treated with individual doses of budipine added to stable conventional antiparkinsonian medication. Tremor activity was measured using long-term electromyogram (EMG) recordings. Tremor intensity was reduced by 25%, tremor occurrence by 34%, and conventional “Unified Parkinson's Disease Rating Scale” (UPDRS) scores improved by 20% with this medication. There were two dropouts because of side effects. One dropout appeared not to be related to budipine. Apart from those, the drug was well tolerated by all patients. We conclude that budipine is an effective and well-tolerated tremorlytic drug and that the method of long-term EMG recording is suitable for tremor quantification in clinical studies.
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