Stimulation of corneal endothelial wound healing in cats by mesodermal growth factor
作者:
RichLarry F.,
HatfieldJ. Michael,
LouiselleIngrid,
ShellarsStephen,
HaraguchiKenneth H.,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 6
页码: 509-516
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999590
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Several growth factors have been evaluated for their effects on corneal wound healing but few studies have yet demonstrated an acceleration of endothelial repairin vivo.Mesodermal Growth Factor (MGF) was testedin vivoby making standardized freeze wounds in cat corneas and immediately injecting one of four concentrations of MGF in sterile phosphate buffered saline (PBS), or PBS alone, into the anterior chamber. Seven days later, the animals were sacrificed and the corneas excised and stained. Descemet's membrane and endothelium were dissected and mounted onto glass slides. The wound areas were photographed, measured and compared statistically.Those cats receiving the three lowest doses of MGF had significantly smaller wounds than controls (p<0.05).
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