Pharmacokinetic Modelling of a Parent Drug and its MetaboliteAtracurium and Laudanosine
作者:
Vladimir Nigrovic,
Mark Banoub,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1992)
卷期:
Volume 22,
issue 5
页码: 396-408
ISSN:0312-5963
年代: 1992
出版商: ADIS
数据来源: ADIS
摘要:
A pharmacokinetic model was designed to describe simultaneously the plasma concentrations of atracurium and its metabolite laudanosine. The proposed model satisfactorily fits the observations and is based on the assumptions that the parent drug spontaneously degrades to laudanosine at the rate comparable with that observedin vitroat pH 7.4 and 37°C; that 2 molecules of laudanosine are formed from 1 molecule of atracurium; that an initial very rapid decay of a fraction of the atracurium dose is responsible for the initially high plasma laudanosine concentrations; that the rapid disappearance of atracurium from plasma is accounted for by its spontaneous degradation and by the sequestration of atracurium in a deep compartment; and that laudanosine formed from atracurium is added to its central compartment, with its disposition described by a simple 2-compartment model with elimination from the central compartment. The model projects that about 43% of the atracurium dose is rapidly converted to laudanosine and that nearly the whole injected amount of atracurium is degraded to laudanosine.
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