Comparative Study of the Activity and Lingering Effect of Topical Antifungals
作者:
Gérald E. Piérard,
Claudine Piérard-Franchimont,
Jorge Arrese Estrada,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1993)
卷期:
Volume 6,
issue 3
页码: 208-214
ISSN:1660-5527
年代: 1993
DOI:10.1159/000211137
出版商: S. Karger AG
关键词: Antifungal;Stratum corneum;Dermatophyte;Yeast
数据来源: Karger
摘要:
We present a combined method of culturing pathogenic der-matophytes and yeasts on human stratum corneum. Topical marketed antifungals are applied in vivo, and the stratum corneum is removed by cyanoacrylate skin surface strippings. After inoculation of the test organism, the extent of fungal growth is measured, indicating by comparison with controls the level of inhibitory effect of the antifungal. Other samples of stratum corneum collected at different time intervals after the arrest of antimicrobial treatment are used to evaluate the lingering effect of the drug. The combination of the data gained by these approaches close to the in vivo situation is used to introduce a classification of antifungals.
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