The Relative Efficacy of Fluoxetine and Manual-Based Self-Help in the Treatment of Outpatients With Bulimia Nervosa
作者:
James Mitchell,
Linda Fletcher,
Karen Hanson,
Melissa Mussell,
Harold Seim,
Ross Crosby,
Mahir Al-Banna,
期刊:
Journal of Clinical Psychopharmacology
(OVID Available online 2001)
卷期:
Volume 21,
issue 3
页码: 298-304
ISSN:0271-0749
年代: 2001
出版商: OVID
数据来源: OVID
摘要:
A randomized, placebo-controlled study was conducted examining the singular and combined effects of fluoxetine and a self-help manual on suppressing bulimic behaviors in women with bulimia nervosa. A total of 91 adult women with bulimia nervosa were randomly assigned to one of four conditions: placebo only, fluoxetine only, placebo and a self-help manual, or fluoxetine and a self-help manual. Subjects were treated for 16 weeks. Primary outcome measures included self-reports of bulimic behaviors. Fluoxetine and a self-help manual were found to be effective in reducing the frequency of vomiting episodes and in improving the response rates for vomiting and binge-eating episodes. Furthermore, both factors were shown to be acting additively on the primary and secondary efficacy measures in this study. Results are discussed in relation to previous research and the implications for treatment of bulimia nervosa.
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