Release of Granulocyte Proteinases during Hemodialysis
作者:
Walter H. Hörl,
Marianne Jochum,
August Heidland,
Hans Fritz,
期刊:
American Journal of Nephrology
(Karger Available online 1983)
卷期:
Volume 3,
issue 4
页码: 213-217
ISSN:0250-8095
年代: 1983
DOI:10.1159/000166713
出版商: S. Karger AG
关键词: Hemodialysis;Granulocytes;Elastase;α1-Proteinase inhibitor
数据来源: Karger
摘要:
Neutral proteinases of neutrophilic polymorphonuclear leukocytes were followed up cytochemically in blood smears of 12 patients submitted to regular hemodialysis treatment (RDT). Halo formation (ring-shaped area around each neutrophil due to protein degradation) was reduced in all patients with end-stage renal disease under RDT. Concomitant to the development of leukopenia, a maximal increase of the plasma levels of the granulocytic elastase in complex with αi-proteinase inhibitor was observed 3 h after starting hemodialysis (+409%; p < 0.001). On the other hand, the proteolytic activity of the plasma samples against azocasein as substrate, being significantly higher (+244%; p < 0.001) in RDT patients compared with healthy controls, decreased permanently during therapy (-71 %; p < 0.001; 3 h after initiation of the treatment). The mechanisms of release as well as of elimination of proteolytic activity due to RDT are discussed
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