Expression of Kit and platelet-derived growth factor receptors &agr; and &bgr; in cholangiocarcinoma, and case report of therapy with imatinib mesylate (STI571)
作者:
Randall Holcombe,
Mai Gu,
David Imagawa,
Tatjana Milovanovic,
期刊:
Anti-Cancer Drugs
(OVID Available online 2003)
卷期:
Volume 14,
issue 8
页码: 651-657
ISSN:0959-4973
年代: 2003
出版商: OVID
关键词: c-kit;cholangiocarcinoma;imatinib mesylate;tyrosine kinases
数据来源: OVID
摘要:
We have evaluated the expression of Kit, a receptor encoded by the c-kitprotooncogene, and platelet-derived growth factor-receptors (PDGF-R) &agr; and &bgr; in cholangiocarcinoma specimens from 13 separate patients, and provide a case report of a therapeutic trial of imatinib mesylate in one patient. Archived pathologic samples from 13 patients with cholangiocarcinoma were obtained. Tissue sections were hybridized with anti-Kit, anti-PDGF-R&agr; and anti-PDGF-R&bgr; monoclonal antibodies. Kit, PDGF-R&agr; and PDGF-R&bgr; expression was seen in 31, 69 and 46% of samples, respectively. All patients with PDGF-R&bgr; expression also expressed PDGF-R&agr;. Three out of four patients with Kit expression did not express either PDGF receptor and only one patient exhibiting expression of PDGF expressed Kit. Cohen's κ statistic demonstrated that PDGF and Kit expression were inversely correlated with borderline significance (p=0.052; κ=−0.4742, 95% confidence interval –0.9821 to 0.03364). In one case, strong Kit expression was noted in a tumor from a metastatic lymph node, but was absent in the primary tumor, suggesting that Kit may be related to invasive or metastatic potential. Given the high level of expression defined in this study, a prospective clinical trial incorporating imatinib mesylate, alone or in combination with cytotoxic chemotherapy, and especially in chemotherapy-naive patients, should be considered for patients with cholangiocarcinoma.
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