Adrenocortical dysfunction in acute medical illness
作者:
DANIEL DRUCKER,
JOHN MCLAUGHLIN,
期刊:
Critical Care Medicine
(OVID Available online 1986)
卷期:
Volume 14,
issue 9
页码: 789-791
ISSN:0090-3493
年代: 1986
出版商: OVID
数据来源: OVID
摘要:
To further characterize the adrenocortical response to acute illness, we measured basal and adrenocorticotropic hormone (ACTH)-stimulated 11-deoxycortisol, androstenedione, and dehydroepiandrosterone sulfate (DHEAS). Acutely ill patients had higher ACTH-stimulated 11-deoxycortisol and androstenedione, and decreased basal and ACTH-stimulated androstenedione/ Cortisol and DHEAS/cortisol ratios. Our data suggest that a shift away from androgen synthesis toward the glucocorticoid pathway occurs in acute illness.
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