Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia
作者:
KuppnerM. C.,
LiversidgeJ.,
McKillopS.,
LumsdenL.,
ForresterJ. V.,
期刊:
Current Eye Research
(Taylor Available online 1993)
卷期:
Volume 12,
issue 10
页码: 923-934
ISSN:0271-3683
年代: 1993
DOI:10.3109/02713689309020399
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Samples of iris ciliary body, choroid and retina from normal eyes and from 2 cases of sympathetic ophthalmitis (one acute and one late stage fibrosis) were examined for the expression of the VLA integrins pl and a 1-6, and the integrinβ3, in addition to ICAM-1, VCAM-1, ELAM-1 and CD44 using an APAAP staining technique.The expression of VLA-4, VLA-5, VCAM-1, ICAM-1, and CD44 was significantly increased and ELAM-1 was slightly increased in acute sympathetic ophthalmitis in comparison to fibrotic and normal eyes.VLA-6 was moderately increased in acute and fibrotic cases and VLA-2 VLA-3 and p 3 were moderately expressed on all tissues examined. The differential expression of molecules known to be involved in lymphocyte activation and adhesion in acute sympathetic ophthalmitis suggests that certain adhesion molecules play a role in the pathogenesis of intraocular inflammation and may be suitable targets for immunotherapy.
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