Some Evidences for the Hypothesis of Active Transport of Streptomycin inPseudomonas aeruginosa
作者:
Silvio A.C. Camba,
Flavio Alterthum,
Lucio P. de Carvalho Lima,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 6
页码: 341-345
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221945
出版商: S. Karger AG
关键词: Active transport;Streptomycin;Pseudomonas aeruginosa
数据来源: Karger
摘要:
New evidence is presented in support of the hypothesis put forth by Camba et al. [1] that streptomycin enters bacterial cells by a process of active transport. In this paper a general inhibitor of transport, uranyl nitrate, when added to the bacterial suspension prior to the addition of streptomycin, was shown to significantly increase the resistance to the drug. Furthermore, in suspensions of cells with a progressively exhausted endogenous metabolism and consequently with less available energy, a corresponding increase in the amount of streptomycin remaining in the supernatant was observed.
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