Protein Kinase C Activators and Calcium-Mobilizing Agents Synergistically Increase GH, LH, and TSH Secretion from Anterior Pituitary Cells
作者:
Allan M. Judd,
Koji Koike,
Takeshi Yasumoto,
Robert M. MacLeod,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 3
页码: 197-202
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124440
出版商: S. Karger AG
关键词: Phorbol esters;Thyroid-stimulating hormone;Luteinizing hormone;Growth hormone;Diacylglycerol;Protein kinase C
数据来源: Karger
摘要:
A series of studies was designed to determine the effects of protein kinase C activators on TSH, LH, and GH release from anterior pituitary cells. A 15-min incubation of cultured pituitary cells with synthetic diacylglycerol or phorbol myristate acetate, stimulators of protein kinase C, increased GH, LH, and TSH release. Similarly phospholipase C, which liberates endogenous diacylglycerol, stimulated GH, LH, and TSH secretion. The potentiation of the effects of protein kinase C activators is achieved by calcium mobilization in various cell types. The results of the present studies show that calcium ionophore A23187 or calcium channel activator maitotoxin potentiate diacylglycerol-, phorbol ester-, or phospholipase C-induced GH, LH, or TSH release. These findings suggest that activation of protein kinase C by diacylglycerol and mobilization of calcium may be synergistically involved in the regulation of GH, LH, and TSH release.
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