Effect of Antioxidants on Ammonia Induced Cns-Renal Pathobiology in Sheep
作者:
GuerriniVincent H.,
期刊:
Free Radical Research
(Taylor Available online 1994)
卷期:
Volume 21,
issue 1
页码: 35-43
ISSN:1071-5762
年代: 1994
DOI:10.3109/10715769409056553
出版商: Taylor&Francis
关键词: Antioxidants;ammonia;pathobiology;sheep
数据来源: Taylor
摘要:
The effect of antioxidants on ammonia induced CNS and renal pathobiology in 10 sheep infested byL. Cuprinalarvae was investigated. The condition produces severe dermatitis, proliferation of macro-phages and hyperammonaemia, and free radicals may therefore be involved in the pathogenesis. Five of the sheep (treated group) were given daily intramuscular (im) injections of 2 g sodium ascorbate, 5.9 g dl-alpha tocopherol (11 days) and 3 g desferrioxamine mesylate (6 days) with 70 mg oral butylated-hydroxyanisole (11 days). The treatment prevented rises in jugular ammonia, creatinine, urea, sodium and pH, and decreases in water intake, urine output and glucose. The findings showed that antioxidants prevented ammonia induced CNS and renal pathobiology and suggest that free radicals contribute to the pathogenesis of the condition.
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