Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice
作者:
F. D. Andrew,
R. E. Staples,
期刊:
Teratology
(WILEY Available online 1977)
卷期:
Volume 15,
issue 1
页码: 25-32
ISSN:0040-3709
年代: 1977
DOI:10.1002/tera.1420150104
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractMedroxyprogesterone acetate (MPA) was given once daily sc at 0.1–3,000 mg/kg/day for 3, 6, or 9 consecutive days during gestation days 7 to 15 to GDI and A/J mice, and New Zealand (NZ) and Dutch Belted (DB) rabbits, and during days 8 to 16 to CD rats. Malformations attributable to MPA did not occur in fetuses of mice or rats exposed to the largest dosage tested. However, 1, 3, or 10 mg/kg on days 13 to 15 to NZ rabbits resulted in 6, 28, and 42% cleft palate, respectively. Comparable cleft palate frequencies were seen in DB offsprin
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