An Ultrastructural Study of Transcutaneous Migration of Polymorphonuclear Leukocytes following Application of Leukotriene B4
作者:
M. Paulissen,
J.H.J. Copius Peereboom-Stegeman,
P.C.M. van de Kerkhof,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1990)
卷期:
Volume 3,
issue 4
页码: 236-247
ISSN:1660-5527
年代: 1990
DOI:10.1159/000210876
出版商: S. Karger AG
关键词: Endothelium;Inflammation;Leukotrienes;Polymorphonuclear leukocytes;Psoriasis
数据来源: Karger
摘要:
In the present study the ultrastructural aspects of the migration of polymorphonuclear leukocytes (PMN) in apparently normal skin following the epicutaneous application of leukotriene B4 (LTB4) were studied and it was investigated whether this model is representative of the migration of PMN in psoriatic skin. At the ultrastructural level the following features were observed: degranulation of PMN, formation of fenestrations and gaps of the endothelium, a multilayered basal lamina and hyperactive endothelial cells with protrusions and focal necrosis of these cells. Epicutaneous application of LTB4 is a practical approach to study the dynamics of the interaction between PMN and the endothelium in vivo.
点击下载:
PDF
(1456KB)
返 回