Levels of Cofactors for Lipoprotein Lipase and Lecithin-Cholesterol Acyltransferase in Plasma Patients With Severe Thermal Injury
作者:
Gloria Vega,
Petar Alaupovic,
Zu-Jun Zhang,
Gayathri Tenjarla,
Charles Baxter,
Cynthia Stenoien,
期刊:
Journal of Burn Care & Rehabilitation
(OVID Available online 1988)
卷期:
Volume 9,
issue 1
页码: 18-21
ISSN:0273-8481
年代: 1988
出版商: OVID
数据来源: OVID
摘要:
Transient hypertriglycericlemia occurs in patients with severe thermal injury, and some patients have a low learance of exogenous triglyceride (TG) from plasma. This suggests an impaired lipolysis. In the current study, we measured the levels of apolipoproteins required for clearance of endogenous and/or exogenous TG. Twenty-five thermal injury patients (18 men and 7 women) having an average of 52% ± 6% (SE) total burn surface area were followed for a period of nine weeks. The levels of plasma lipids and apolipoproteins C-II, C-III, E, and A-I were measured after a 12-hour “fast,” ie, prior to the parenteral administration of fat emulsion. The levels of plasma cholesterol and apolipoproteins C-II, C-III, and A-I were low. Plasma TG levels, however, were not abnormally elevated, while apo E levels were within normal range. The results indicate that therm-ally injured patients have reduced levels of apoproteins necessary for TG metabolism. This condition may predispose to intolerance of exogenous TG.
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