Central Release of Oxytocin, Vasopressin and Neurophysin by Magnocellular Neurone Depolarization: Evidence in Slices of Guinea Pig and Rat Hypothalamus
作者:
W. Thomas Mason,
Glenn Irwin Hatton,
Yuk Wah Ho,
Chris Chapman,
Iain C.F. Robinson,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 4
页码: 311-322
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124457
出版商: S. Karger AG
关键词: Oxytocin;Vasopressin;Neurophysins;Hormone release hypothalamic slice;Supraoptic nucleus;Acetylcholine paraventricular nucleus;Axon collateral
数据来源: Karger
摘要:
Using slices of rat hypothalamus maintained in vitro, we have examined release of oxytocin and vasopressin under conditions of increased neuronal activity. We report here that when the supraoptic or paraventricular nucleus is depolarized with high K+ solutions, hormone is released into areas close to the nucleus. Similar experiments with guinea pig hypothalamus suggest that neurophysin may also be co-released with oxytocin and vasopressin. Use of acetylcholine to selectively stimulate vasopressin neurones appears to evoke a rise in local release of vasopressin but not oxytocin. These results suggest that under conditions of increased neuronal activity, hormones normally secreted from the neurohypophysis are secreted locally into the hypothalamus.
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