High-Dose Chemotherapy of Metastatic Breast Cancer: A Review
作者:
VahdatLinda,
RaptisGeorge,
FennellyDavid,
CrownJohn,
期刊:
Cancer Investigation
(Taylor Available online 1995)
卷期:
Volume 13,
issue 5
页码: 505-510
ISSN:0735-7907
年代: 1995
DOI:10.3109/07357909509024915
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Very-high-dose chemotherapy produces frequent complete responses in patients with metastatic breast cancer. These responses are transient in patients with disease that had relapsed following, or was refractory to, prior conventionally dosed therapy, but when used as first chemotherapy for metastatic disease or as consolidation for patients with responding cancer, a minority achieve durable complete remissions. Improvements in supportive care, especially in hematopoietic support, have resulted in a considerable reduction in the toxicity of this therapy and may allow further intensification through the use of multiple, rapidly cycled courses.
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