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Protection of the hydroxyl function of hydroxyproline and serine in peptide synthesis by the 2‐methoxyethoxymethyl (Mem) group

 

作者: D. VADOLAS,   H.P. GERMANN,   S. THAKUR,   W. KELLER,   E. HEIDEMANN,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1985）
卷期: Volume 25, issue 5  

页码: 554-559

 

ISSN:0367-8377

 

年代: 1985

 

DOI:10.1111/j.1399-3011.1985.tb02210.x

 

出版商: Blackwell Publishing Ltd

 

关键词: maximum protection;2‐methoxyethoxymethyl (Mem)‐group;protection of the hydroxyl function

 

数据来源: WILEY

 

摘要:

Some tri‐ and hexapeptides containing hydroxyproline and serine were synthesized using the 2‐methoxyethoxymethyl group for the protection of the hydroxyl function. ForN‐protection not only the NpS and the Z group but also the Boc group can be used. As compared to the But group the Mem group is much more stable towards TFA. Application of Mem protection allows a complete deblocking of the Boc group without affecting the Mem

 

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