TITRATION STREPTOMYCIN THERAPY IN MENIERE'S DISEASECURRENT CONCEPTS
作者:
Michael LaRouere,
John Zappia,
Malcolm Graham,
期刊:
The American Journal of Otology
(OVID Available online 1993)
卷期:
Volume 14,
issue 5
页码: 474-477
ISSN:0192-9763
年代: 1993
出版商: OVID
数据来源: OVID
摘要:
ABSTRACTSoon after its discovery, streptomycin sulfate was found to be beneficial in the treatment of tuberculosis. However it also was found to have toxic effects, primarily vestibular and typically sparing the auditory nerve until higher doses were administered. The first reported use of streptomycin in the treatment of vertigo was in 1948. This was soon followed by its use for treating Meniere's disease. Although excellent control of vertigo was achieved significant post-treatment oscillopsia was experienced by these completely ablated patients. A protocol of titration streptomycin therapy was established that effectively controls vertigo while decreasing the incidence of oscillopsia. This report presents three patients with Meniere's disease treated with this protocol.
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