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Platelet-Lungin vivoInteractions: an Artifact of a Multi-Purpose Model?

 

作者: B.B. Vargaftig,   J. Lefort,   A.V. Prancan,   M. Chignard,   J. Benveniste,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  (Karger Available online 1979)
卷期: Volume 8, issue 3-5  

页码: 171-182

 

ISSN:1424-8832

 

年代: 1979

 

DOI:10.1159/000214309

 

出版商: S. Karger AG

 

关键词: Arachidonic acid;Bronchoconstriction;Bradykinin;Collagen;Platelet;Platelet activating factor;Thromboxane;Prostaglandins

 

数据来源: Karger

 

摘要:

The simultaneous evaluation of platelet behaviour in vivo and of the accompanying bronchoconstriction in the guinea pig is described. Arachidonic acid induces bronchoconstriction, accompanied by, but independent from, thrombocytopenia, whereas collagen induces bronchoconstriction also accompanied by, but dependent from, thrombocytopenia. In both cases bronchoconstriction is due to cyclo-oxygenase metabolites of arachidonic acid. Use of potential inhibitors of thromboxane synthetase failed to reveal which of prostaglandin endoperoxides or thromboxane A2 is responsible for aspirin-inhibitive bronchoconstriction and thrombocytopenia. In contrast to PGE1 prostacyclin failed to interfere with bronchoconstriction by serotonin or by arachidonic acid, even though thrombocytopenia by the latter was suppressed. Bronchoconstriction by collagen, in contrast, was inhibited by nanogram doses of prostacyclin, confirming platelet-dependency. The combined bronchoconstriction/thrombocytopenia test in guinea pigs can discriminate sites of action of anti-inflammatory drugs, of agents which block specific platelet and/or bronchial receptors, which stimulate the cyclic AMP system, or generically which interfere with the mechanisms of bronchoconstriction and of thrombocytopenia.

 

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