Impaired Corticosteroid Production By Isolated Adrenocortical Cells Of Hypercholesterolemic Rabbits
作者:
TóthI. E.,
SzabóD.,
SzalayK. Sz.,
HeszÁ.,
期刊:
Endocrine Research
(Taylor Available online 1990)
卷期:
Volume 16,
issue 1
页码: 93-105
ISSN:0743-5800
年代: 1990
DOI:10.1080/07435809009035922
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Changes in the structure and function of rabbit adrenocortical cells were studied eight weeks after cessation of a cholesterol-enriched diet. The plasma cholesterol level of the treated animals was still modestly elevated. All three zones of the adrenal cortex contained a slightly increased number of intracellular lipid droplets, and greater number of lipid-laden macrophages were located in the inner layers, as revealed by light and electron microscopy. The basal and ACTH-stimulated hormone production by the isolated adrenocortical cells were significantly inhibited compared with those of the controls. A possible causal relationship between the inhibited adrenocortical hormone production and the increased number of macrophages is discussed.
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