Colorimetric Determination of Some Aromatic Nitrocompounds of Pharmaceutical Interest
作者:
M.I. Walash,
A.M. El-Brashy,
M.A. Sultan,
期刊:
Analytical Letters
(Taylor Available online 1993)
卷期:
Volume 26,
issue 3
页码: 499-512
ISSN:0003-2719
年代: 1993
DOI:10.1080/00032719308016814
出版商: Taylor & Francis Group
关键词: Colorimetric Determination;Nitro-Compounds;Tetrabutylammonium hydroxide
数据来源: Taylor
摘要:
A simple colorimetric method for the determination of six nitro derivatives, namely: furazolidone, nifuroxime, niridazole, nitrazepam, nitrofurantoin and nitrofurazone was described. The suggested method depends upon the formation of orange to purple colour when these nitro compounds react with tetrabutylammonium hydroxide in dimethylformamide. The different experimental parameters were studied and incorporated into the procedure. The mean percentage recoveries ranged from 98.9 ± 0.3 to 100.4 ± 0.7. The proposed method was applied to the determination of certain pharmaceutical dosage forms containing the studied nitro-compounds, as well as furazolidone and nifuroxime in mixture. The results obtained were in agreement with those obtained by official and compendium methods.
点击下载:
PDF (442KB)
返 回