Lack of Differences Among Mitochondrial DNA in Family Members with Leber's Hereditary Optic Neuropathy and Differing Visual Outcomes
作者:
Yukihiko Mashima,
Yoshiki Hiida,
Yoshihisa Oguchi,
期刊:
Journal of Neuro-Ophthalmology
(OVID Available online 1995)
卷期:
Volume 15,
issue 1
页码: 15-19
ISSN:1070-8022
年代: 1995
出版商: OVID
关键词: Leber's hereditary optic neuropathy;Visual recovery;11778 mitochondrial mutation;Idebenone;Alcohol;Tobacco
数据来源: OVID
摘要:
Investigation of a maternal family of three generations of Leber's hereditary optic neuropathy (LHON) showed four affected and three unaffected individuals. Two of the four patients had recovered near-normal vision, one spontaneously, and one following treatment with idebenone, a quinol compound. One patient whose visual impairment persisted was a heavy consumer of alcohol and tobacco. Molecular genetic analysis of 12 known primary or secondary mutations in mitochondrial DNA (mtDNA) associated with LHON revealed only the 11778 mutation in a homoplasmic fashion with no secondary mutations. The variations in clinical outcome thus could not be explained by synergistically interacting secondary mutations in mtDNA. Environmental factors may play an etiologic role in the development of optic atrophy.
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