▴ Tandospirone is a new addition to the azapirone class of anxiolytics, which may be useful for the long term treatment of anxiety and depressive neuroses.▴ It is a serotonin (5-hydroxytryptamine; 5-HT)1Areceptor agonist that has anxiolytic effects.▴ Unlike benzodiazepines. the anxiolytic and anti-depressant effects of tandospirone can be separated from the sedative, anticonvulsant and muscle relaxant effects.▴ The abuse potential of tandospirone appears to be lower than that of benzodiazepines.▴ Tandospirone has anxiolytic effects similar to those of diazepam in patients with various different neuroses.