AbstractA nine‐step procedure for microscale synthesis of ethyl 2‐amino‐6‐{[(4‐fluorophenyl)methyl]amino}‐3‐pyridinyl‐2,6‐14C carbamate maleate [10], [14C]flupirtine maleate, was developed. The synthesis started with the readily avaiable and economical reagents, potassium cyanide‐14C and 1,3‐dibromopropane making the following intermediates: glutaronitrile‐14C [2], glutarimide‐14C [3], 2,6‐dichloropyridine‐2,6‐14C [4], 2,6‐dichloro‐3‐nitro‐pyridine‐2,6‐14C [5], 2‐amino‐3‐nitro‐6‐chloropyridine‐2,6‐14C [6], 2‐amino‐3‐nitro‐6‐(p‐fluorobenzylamino)pyridine‐2,6‐14C [7], 2,3‐diamino‐6‐(p‐fluoro‐benzylamino)pyridine‐2,6‐14C [8], and ethyl 2‐amino‐6‐{[4‐fluoropheny(l)‐methyl]amino}‐3‐pyridinyl‐2,6‐14C carbamic acid ester hydrochloride [9]. The overall yield was 6.3% (5.4 mCi), and the radioac