首页   按字顺浏览 期刊浏览 卷期浏览 Bronze Baby Syndrome: An Animal Model
Bronze Baby Syndrome: An Animal Model

 

作者: GIULIO JORI,   ELENA REDDI,   FIRMINO RUBALTELLI,  

 

期刊: Pediatric Research  (OVID Available online 1990)
卷期: Volume 27, issue 1  

页码: 22-25

 

ISSN:0031-3998

 

年代: 1990

 

出版商: OVID

 

关键词: BBS, bronze baby syndrome

 

数据来源: OVID

 

摘要:

We evaluated the appropriateness of an animal model for the bronze baby syndrome. Ligation of the common bile duct in adult Wistar rats induces an accumulation of porphyrins and copper in the liver and a 20% conversion of protoporphyrin IX into Cu(II)-protoporphyrin IX. Upon irradiation of these animals with superblue lamps, the plasma content of Cu(II)-protoporphyrin increases by about 30%. Cholestasis also increases the recovery of porphyrins in the urine, although light treatment of ligated rats further increases urinary porphyrin excretion. The spectroscopic changes induced by irradiation of sera of ligated rats are consistent with the formation of products that have the typical spectrum found in bronze baby syndrome patients, i.e. a reduced absorbance in the visible region and an increased absorption in near-UV and red spectral regions. The products responsible for the brown discoloration found in bronze baby syndrome seem to result from phototransformation of copper-porphyrins subsequent to an electron transfer between photoexcited bilirubin and the copper ion.

 

点击下载:  PDF (446KB)



返 回