Effects of Retinoic Acid on the Development of the Facial Skeleton in Hamsters: Early Changes Involving Cranial Neural Crest Cells
作者:
M.J. Wiley,
P. Cauwenbergs,
I.M. Taylor,
期刊:
Cells Tissues Organs
(Karger Available online 1983)
卷期:
Volume 116,
issue 2
页码: 180-192
ISSN:1422-6405
年代: 1983
DOI:10.1159/000145741
出版商: S. Karger AG
关键词: Vitamin A;Facial skeleton;Cranial neural crest cells
数据来源: Karger
摘要:
Treatment of gravid hamsters with 60 mg/kg of retinoic acid on the 8th day of pregnancy resulted in facial skeletal defects in 100% of the survivors examined by alizarin staining at term. An investigation of the early stages in the development of these malformations indicated that the teratogen induced delayed and disorganized patterns of cranial neural crest cell migration as well as extensive death and damage of crest cells. The results demonstrate that retinoic acid provides a useful tool for studies in the pathogenesis of facial skeletal abnormalities in vivo. Moreover, the extensive defects seen in the teratogen-treated litters at term, together with the results of the microscopical analyses, support the hypothesis that cranial neural crest cells make an important contribution to the development of the mammalian facial skeleton.
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