The Use of Multiple Restriction Fragment Length Polymorphisms in Prenatal Risk Estimation
作者:
Andrew G. Clark,
期刊:
Human Heredity
(Karger Available online 1987)
卷期:
Volume 37,
issue 1
页码: 41-53
ISSN:0001-5652
年代: 1987
DOI:10.1159/000153676
出版商: S. Karger AG
关键词: Restriction fragment length polymorphisms;Risk estimation;Genetic counseling
数据来源: Karger
摘要:
Although analytical procedures for multiple marker risk estimation are now well established, we still lack a unified optimal procedure for deciding which family members to examine and which markers to use. Towards this goal, the application of conditional risk distributions is developed, along with a suggested statistic for judging the utility of a marker. The conditional risk distribution depends on what knowledge has already been obtained about the pedigree, and indicates the expected outcome of risk estimates after another marker is examined. Population genetic aspects including haplotype frequencies, linkage disequilibrium, family size and pedigree structure and the statistical confidence in the linkage map all influence the optimal strategy for multiple marker risk estimation.
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