Two Cases in Whom Pyrazinamide Does Not Inhibit the Uricosuric Action of Benzbromarone
作者:
Tetsuya Yamamoto,
Yuji Moriwaki,
Sumio Takahashi,
Michio Suda,
Emmanuel Oluyemi Agbedana,
Kazuya Higashino,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 61,
issue 4
页码: 432-434
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186962
出版商: S. Karger AG
关键词: Benzbromarone;Pyrazinamide;Uric acid and kidney
数据来源: Karger
摘要:
The 2 subjects were a diabetic male with renal hypouricemia and a healthy male with normouricemia. In these subjects, 200 mg of benzbromarone increased fractional uric acid clearance (FUa) and 3.0 g of pyrazinamide decreased FUa. However, pyrazinamide did not inhibit the uricosuric action of benzbromarone at all on the administration of 3.0 g of pyrazinamide together with 200 mg of benzbromarone. These results indicated that in these cases, the relative role of each component could not be determined on the basis of the hypothetical four-component model.
点击下载:
PDF
(522KB)
返 回