Nephrotoxic Effects of Aminoglycoside Treatment on Renal Protein Reabsorption and Accumulation
作者:
Constantin Cojocel,
Nicolae Dociu,
Elena Ceacmacudis,
Karl Baumann,
期刊:
Nephron
(Karger Available online 1984)
卷期:
Volume 37,
issue 2
页码: 113-119
ISSN:1660-8151
年代: 1984
DOI:10.1159/000183225
出版商: S. Karger AG
关键词: Proteins;Aminoglycoside nephrotoxicity;Scanning electron microscopy;Glomerular endothelium changes;GFR decrease;Reabsorption and accumulation impairment
数据来源: Karger
摘要:
To quantify the effects of gentamicin, kanamycin and netilmicin on renal protein reabsorption and accumulation, these drugs were administered to rats intraperitoneally (30 mg/kg/day) for 7, 14 or 21 days. Scanning electron microscopy of the glomerular endothelia, urinary measurements of sodium, potassium, endogenous lysozyme, N-acetyl-β-D-glucosaminidase (NAG) as well as clearance and accumulation experiments after i.v. administration of egg-white lysozyme and measurements of inulin clearance (GFR) were done in each treatment group. Gentamicin administration decreased diameter, density and shape of endothelial fenestrae. Kanamycin and netilmicin appeared to have no effect at the dose used. All three aminoglycosides decreased GFR and increased urinary excretion of sodium and potassium. While gentamicin and kanamycin decreased the percentage reabsorption and accumulation of lysozyme after i.v. administration of egg-white lysozyme netilmicin had no effect. Daily excretion of total protein, endogenous lysozyme and NAG increased only after treatment with kanamycin and gentamicin. Thus, aminoglycosides may act as nephrotoxicants at glomerular and/or tubular level inducing impairment of renal reabsorption and accumulation of proteins
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