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Acetylation, deacetylation and hydroxylation of sulphamethoxazole and N4‐acetylsulphamethoxazole in the turtle Pseudemys scripta elegans

 

作者: TomB. Vree,   JeroenB. Vree,   YechielA. Hekster,   JacquesF. M. Nouws,  

 

期刊: Veterinary Quarterly  （Taylor Available online 1987）
卷期: Volume 9, issue 4  

页码: 381-384

 

ISSN:0165-2176

 

年代: 1987

 

DOI:10.1080/01652176.1987.9694130

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

The turtle Pseudemys scripta elegans is able to hydroxylate and acetylate Sulphamethoxazole in a way that is comparable to man, i.e the rate and yield of hydroxylation equals that of the acetylation. The hydroxy metabolites 5‐hydroxy‐ and N4‐acetyl‐5‐hydroxysulphamethoxazole are not glucuronidated. N4‐acetysulphamethoxazole is neither deacetylated nor hydroxylated.

 

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