Protective immunity against herpetic ocular disease in an outbred mouse model
作者:
MetcalfJoseph F.,
WhitleyRichard J.,
期刊:
Current Eye Research
(Taylor Available online 1987)
卷期:
Volume 6,
issue 1
页码: 167-171
ISSN:0271-3683
年代: 1987
DOI:10.3109/02713688709020085
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Immunization of outbred mice by subdermal (footpad) inoculation with the F strain of herpes simplex virus type 1 (HSV-1) induces an immune response which protects the animals against herpetic ocular disease and encephalitis, and reduces the incidence of latent trigeminal ganglion infections following corneal challenge with the RE strain of HSV type 1. The protective effects are proportional to the dose of virus used for immunization. Heat-killed virus preparations also protected the mice against encephalitis and stromal keratitis, but failed to prevent epithelial keratitis and establishment of latency.
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