Patients diagnosed with hemophilia, a chronic hereditary deficiency of the coagulation mechanism, require expert care and management to minimize the potentially devastating side effects of this complicated disease. Hemophilia treatment centers are designated medical facilities where comprehensive careis readily available to treat the patient with clotting factor deficiencies and to screen for potential complications.Although there is no cure for hemophilia to date, current advances in technology and medical management have facilitated and expanded home therapy/self-infusion programs to treat bleeding episodes early, improve the quality of life. and lessen the morbidity. This article will review both hemophilia A and hemophilia B, presenting both the clinical and the psychosocial aspects and highlighting current trends and advances