Role of Glutathione for Cisplatin Nephrotoxicity in Young and Adult Rats
作者:
AppenrothDorothea,
WinnefeldKlaus,
期刊:
Renal Failure
(Taylor Available online 1993)
卷期:
Volume 15,
issue 2
页码: 135-139
ISSN:0886-022X
年代: 1993
DOI:10.3109/08860229309046144
出版商: Taylor&Francis
关键词: Ac-cys;BSO;Cisplatin;Developing rats;GSH;Nephrotoxicity
数据来源: Taylor
摘要:
Investigations were done in 10- and 55-day-old Wistar rats. Glutathione (GSH) level in kidney was decreased by 8 mmol buthionine sulfoximine (BSO)I100 g BW. There was no effect on the renal function and nephrotoxicity of cisplatin (0.6 mg CPI100 g BW) in adult rats. In young rats BSO treatment was followed by neph-rotoxic effects. Pt concentration remained unaffected by BSO in young and adult rats. GSH concentration in kidney was increased by 100 mg acetyl-cysteine (ac-cys)/100 g BW. CP nephrotoxicity was lower in young as well as in adult ac-cys-treated rats. Pt levels in renal tissue were significantly decreased in rats from both age groups. From our results we conclude that the beneficial effect of high GSH concentration in renal tissue on CP nephrotoxicity is the result of decreased Pt concentration in kidney.
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